How do Genostim® Isotide™ peptides and growth factors work?
This peptide is quite complex, the Genostim® Isotide™ pass intact through the gut into the blood stream, mainly by pinocytosis.
This peptide is characterized as an adoptogenic on (i.e a product that modify the equilibrium of hormones secreted by the adrenal cortex). This adoptogenic activity is a consequence of fine-tuning exerted by the natural growth factors from the Isotide™ peptide extract on the adrenal cortex. Due its mechanism of action (regulation by the growth factors in a paracrine manner of adrenal cortex activity) the growth factors from the Isotide™ peptides modify the equilibrium of all the hormones secreted by the adrenal glands, as is proved by the increase of urinary 17-KS-S.
Also, these peptides stimulate the division of mature cells and significantly decrease the mortality of older cells.
So, the mechanism of action of Genostim® Isotide™ are:
1. Regulates the adrenal cortex hormone activity (androgens, glucocorticoids, mineral-corticoids.
2.At cellular and tissue level by exert cyto-stimulating, cyto-protective and ant oxidative properties.
Below is a list of the naturally occurring Growth Factors found in Genostim® products.
TGF-B : (Transforming Growth Factor-Beta) Peptides that promote healing of wounds and are anti-inflammatory.
TNF-A, TNF-B : (Tumor Necrosis Factors Alpha and Beta) – peptides that increase cellular responsiveness to growth factors and induce signaling pathways that leads to cellular proliferation.
CTGF: (Connective Tissue Growth Factors)- peptides that promote collagen accumulation in the body. Experimental and clinical tests have revealed that Genostim GS-6® induces a highly significant increase in key adrenal hormones like 17-ketosteroid sulfates and 17-hydroxycorticosteroids. Genostim GS-6® has also been shown to increase plasma concentrations of DHEA, DHEA-S, and testosterone—all while normalizing elevated cortisol levels.
EGF: (Epidermal Growth Factors)- polypeptide’s that promote skin tissue growth and development as well as wound healing.
NGF : (Nerve Growth Factors)- peptides that promote neural cell survival.
FGF : (Fibroblast Growth Factors)- a family of peptides that play a prominent role in the development of the skeletal and nervous system.
GHK-Cu: Can promote activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth.